1-Methyl-4-pyrazole boronic acid pinacol ester

Product Name: 1-Methyl-4-pyrazole boronic acid pinacol ester
CAS No.: 761446-44-0
Chemical Name: 1-Methyl-4-pyrazole boronic acid pinacol ester
Synonyms: 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1H-Pyrazole, 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-Methyl-4-(4;Angelica oil 8015-64-3;e-4-boronic acid pinacoL;1-Methylpyrazole-4-boroni...;1-Methyl-4-(4,4,5,5-Tetramethy
CBNumber: CB0414153
Molecular Formula: C10H17BN2O2
Formula Weight: 208.07
MOL File: 761446-44-0.mol

More

Less

1-Methyl-4-pyrazole boronic acid pinacol ester Property

Melting point:: 59-64 °C(lit.)
Boiling point:: 308.3±15.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (slightly), Methanol (Slightly)
pka: 2.09±0.10(Predicted)
form: Crystals
color: Off-white to yellow
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3
InChIKey: UCNGGGYMLHAMJG-UHFFFAOYSA-N
SMILES: N1(C)C=C(B2OC(C)(C)C(C)(C)O2)C=N1
CAS DataBase Reference: 761446-44-0(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn,F,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant/Flammable
TSCA: No
HazardClass: IRRITANT
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 595314
Product name: 1-Methylpyrazole-4-boronic acid pinacol ester
Purity: 95%
Packaging: 1g
Price: $33.88
Updated: 2024/03/01

Sigma-Aldrich

Product number: 595314
Product name: 1-Methylpyrazole-4-boronic acid pinacol ester
Purity: 95%
Packaging: 5g
Price: $114.6
Updated: 2024/03/01

TCI Chemical

Product number: M2339
Product name: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $52
Updated: 2024/03/01

TCI Chemical

Product number: M2339
Product name: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $66
Updated: 2024/03/01

Alfa Aesar

Product number: H53139
Product name: 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester, 97%
Packaging: 1g
Price: $108.65
Updated: 2024/03/01

More

Less

1-Methyl-4-pyrazole boronic acid pinacol ester Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powde

Uses

suzuki reaction

Uses

1-Methyl-4-pyrazole boronic acid pinacol ester is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.

Synthesis

To the solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.40 g, 2.06 mmol) in THF (10 mL) was added NaH (0.1.00 g, 4.12 mmol) followed by methyl iodide (0.25 mL, 4.12 mmol) at 0° C and the reaction mixture was stirred at ambient temperature for 4 hr. The reaction was quenched with saturated NH4Cl solution (20 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with brine (20 mL), dried over sodium sulfate, and distilled under reduced pressure to obtain 1-Methyl-4-pyrazole boronic acid pinacol ester.

1-Methyl-4-pyrazole boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Trimethyl borate Pinacol Potassium hydroxide 4-Bromopyrazole Tetrahydrofuran 5A molecular sieve Methyl bromide Iodomethane n-Butyllithium

Preparation Products

More

Less

1-Methyl-4-pyrazole boronic acid pinacol ester Suppliers

Americas 1 Belgium 1 China 341 Europe 1 France 1 Germany 6 India 13 Italy 1 Japan 3 Switzerland 3 United Kingdom 8 United States 35 Global 414

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6027
Advantage: 65

AbaChemScene

Tel: 732-484-9848
Fax: 888-484-5008
Email: sales@chemscene.com
Country: United States
ProdList: 3986
Advantage: 60

BOC Sciences

Tel: +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19743
Advantage: 58

Alfa Chemistry

Tel: +1-5166625404
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 21317
Advantage: 58

RR Scientific LLC

Tel: +86-13917743231
Email: sales@rrscientific.com
Country: United States
ProdList: 878
Advantage: 58

Accela ChemBio Inc.

Tel: (+1)-858-699-3322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 19965
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63711
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19639
Advantage: 58

More

Less

View Lastest Price from 1-Methyl-4-pyrazole boronic acid pinacol ester manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1-Methylpyrazole-4-boronic acid pinacol ester 761446-44-0
Price: US $30.00-2.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: g-kg-tons,free sample is available
Release date: 2024-01-03

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Methyl-4-pyrazole boronic acid pinacol ester 761446-44-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 761446-44-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

761446-44-0, 1-Methyl-4-pyrazole boronic acid pinacol esterRelated Search:

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Kresoxim-methyl Tris(trimethylsilyl)phosphate Metazachlor Methyl salicylate Pyraclostrobin Methanol Methylparaben Mefenpyr-diethyl Pinacol Pyrazole Tolyltriazole Methyl acrylate Basic Violet 1 Tribenuron methyl METSULFURON METHYL Zolpidem tartrate Methyl

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-

1-METHYL- 4-PYRAZOLEBORONIC ACID PINACOL ESTER

1-METHYL-4-(4,4,5,5-TERAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

1-methyl-4-(4，4，5，5-tetramethyl-1，3，2-dioxaborolan-2-yl)-1H-

1-Methyl-4-pyrazoleboronic acid pinacol ester, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Methyl-4-(4,4,5-trimethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+%

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

2-(1-Methylpyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methylpyrazole

1-Methyl-4-(4,4,5,5-Tetramethy

1-Methyl-4-Pyridineboronic acid pinacol ester

1H-Pyrazole, 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

1-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(1-Methyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-Methylpyrazole-4-boronic acid pinacol ester 95%

1-Methylpyrazole-4-boronic acid pinacol ester 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Methyl-1H-pyrazole-4-boronic acid, pinacol ester 99%

1-Methyl-1H-pyrazole-4-boronic acid pinacol

-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan

3-hydroxy-2,3-diMethylbutan-2-yl hydrogen 1-Methyl-1H-pyrazol-4-ylboronate

1-METHYL-4-1H-PYRAZOLEBORONIC ACID, PINACOL ESTER

1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-1H-PYRAZOLE

1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER

1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole1-Methylpyrazole-4-boronic acid pinacol ester

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole ,95%

1-Methylpyrazole-4-boronic acid pinacol ester ,98%

1-Methylpyrazole-4-boroni...

1-Methyl-4-(4

1-Methy-4-(4,4,5,5,-tertamethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Methylpyrazole-4-boronic acid pinacol ester (Related Reference)

1-MethylPyrazole-4-Boronic acid Pinacolate

1-methyl-4-(4-tetramethyl-1-dioxaborolan-2-yl)-1H-

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole&gt

e-4-boronic acid pinacoL

(1-METHYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER

2-(1-Methyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1- methylpyrazole -4- boracic acid methyl alcohol ester

Angelica oil 8015-64-3

Tranexamic Acid Impurity 27-13C2

761446-44-0

761446-18-6

76146-44-0

C10H17BN2O2

C10H19BN2O3

Boronate Esters

Boronic Acids and Derivatives

Chemical Synthesis

Heteroaryl Boronate Esters

Organometallic Reagents

Heterocyclic Building Blocks

Organoborons

Pyrazole

Boronic acid